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U'rchatz
Ritual handwashing is very old - it goes back to the days of King Solomon! It reminds us that we should approach eating a meal with respect. Ritual hand-washing with a bracha is done before eating bread (or matza), since bread is a sign that a meal is going to be eaten. But some rabbis taught that it is also done before eating food dipped in liquid, which is what comes next in the Seder.

Since customs vary here, the custom at the Seder is to do the hand-washing without the bracha.